RP-HPLC AND CHEMOMETRIC METHODS FOR THE DETERMINATION OF TWO ANTI-DIABETIC MIXTURES; METFORMIN HYDROCHLORIDE-CANAGLIFLOZIN AND METFORMIN HYDROCHLORIDE-GLICLAZIDE IN THEIR PHARMACEUTICAL FORMULATION
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چکیده
منابع مشابه
Development And Validation Of A Hplc Method For The Determination Of Metformin Hydrochloride, Gliclazide And Piogliglitazone Hydrochloride In Multicomponent Formulation
A simple, rapid, and precise reversed-phase high-performance liquid chromatographic method for simultaneous analysis of metformin hydrochloride, gliclazide, and pioglitazone hydrochloride in a tablet dosage form has been developed and validated. Chromatography was performed on a 25 cm × 4.6 mm i.d., 5-μm particle, C18 column with 85:15 (v/v) methanol: 20 mM potassium dihydrogen phosphate buffer...
متن کاملMultivariate chemometric assisted analysis of metformin hydrochloride, gliclazide and pioglitazone hydrochloride in bulk drug and dosage forms.
PURPOSE In this work a numerical method, based on the use of spectrophotometric data coupled to partial least squares (PLS) regression and net analyte preprocessing combined with classical least square (NAP/CLS) multivariate calibration, is reported for the simultaneous determination of metformin hydrochloride (MET), gliclazide (GLZ) and pioglitazone hydrochloride (PIO) in synthetic samples and...
متن کاملSelective Spectrophotometric Determination of Metformin Hydrochloride in Pharmaceuticals and Urine Using Two Nitrophenols as Chromogenic Agents
Metformin hydrochloride (MFH) is an oral anti-diabetic drug of biguanide class. Two selective spectrophotometric methods were presented for the determination of MFH in pharmaceuticals. The methods were based on the measurement of yellow-coloured charge-transfer complexes formed between MFH and two poly-nitrophenols, namely, 2,4-dinitrophenol (DNP method, at 405 nm) and picric acid (PA met...
متن کاملValidated Rp- Hplc Method for Simultaneous Estimation of Metformin Hydrochloride and Benfotiamine in Bulk Drug and in Pharmaceutical Dosage Form
A new simple, precise, accurate, selective and economical RP-HPLC method has been developed and validated for simultaneous estimation of Metformin Hydrochloride (MET) and Benfotiamine (BEN) in tablet dosage form. The method was carried out on a Waters column C-18 (250 mm x 4.6 mm, 5 μm) with a mobile phase consisting of water (pH 3.2 adjusted with ortho-phosphoric acid) and acetonitrile (75:25 ...
متن کاملPharmaceutical equivalent dissertation of Metformin hydrochloride brands.
The aim of study is to establish pharmaceutical equivalence of different brands of Metformin tablets available in Karachi, Pakistan. The quality control parameters which are studied are weight variation test, hardness test, thickness, friability, disintegration and dissolution specified by BP/USP (British and United State Pharmacopoeia). Weight variation and hardness value requirement was compl...
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ژورنال
عنوان ژورنال: International Journal of Pharmacy and Pharmaceutical Sciences
سال: 2019
ISSN: 0975-1491,2656-0097
DOI: 10.22159/ijpps.2020v12i2.35415